Androgenetic Alopecia: An Evidence-Based Treatment Update

  title={Androgenetic Alopecia: An Evidence-Based Treatment Update},
  author={Supenya Varothai and Wilma Fowler Bergfeld},
  journal={American Journal of Clinical Dermatology},
BackgroundAndrogenetic alopecia (AGA) is one of the most common chronic problems seen by dermatologists worldwide. [] Key Method MEDLINE, EMBASE and Cochrane Library were searched for systematic reviews, randomized controlled trials, open studies, case reports and relevant studies of the treatment of male and female AGA. The relevant articles were classified according to grade and level of evidence.ResultsThe medical treatments with the best level of evidence classification for efficacy and safety for male…

LITERATURE REVIEW Update Treatment of Male Androgenetic Alopecia

The MAGA therapy is expected to achieve cosmetically significant regrowth and to slow additional hair loss and to affect patients’ quality of life and self-esteem.

New drugs under investigation for the treatment of alopecias

A literature search of PubMed/MEDLINE and was performed to gather information about active research on new treatments for alopecias and found that stem-cell research is advancing and the goal to create new follicles or refresh dormant follicles may be realized in the near future.

Conventional and novel stem cell based therapies for androgenic alopecia

The therapeutic agents that have been used for androgenic alopecia are analyzed and the potential of new therapies based on advances in stem cell technologies and regenerative medicine are emphasized.

Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

Most of the studies reviewed showed effectiveness of PRP in increasing terminal hair density/diameter in AGA, and additional investigations are needed to determine the optimal treatment regimen for high efficacy ofPRP in AGA.

Opções terapêuticas e perspectivas no tratamento da alopecia androgenética

The main therapeutic forms for androgenetic alopecia in both sexes are presented and the need for research on some drugs and on the association between certain treatments, as well as some advantages among them is noted.

Pharmacological Treatment of Alopecia

In this chapter, this chapter will review current pharmacological treatments for alopecia and selected treatments under development, including those with significant preclinical or clinical data which have appeared in the published literature.

Review Epidemiology and Treatment of Male Androgenetic Alopecia

The existing therapies for androgenetic alopecia are effective in slowing the disease's progression, they only allow for partial hair restoration, and further research can aid in developing new treatment strategies.

Female patients with androgenetic alopecia: immunohistochemical picture of scalp biopsies

The data obtained by this study helps to improve the concept of morphogenesis of AGA, and also can become a base for improving the standards of treatment of the disease.

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

It is suggested that combination therapy could be an effective, safe and promising option for the treatment of AGA, however, more RCTs are needed to further investigate and confirm the efficacy of combined treatment.



Male androgenetic alopecia

Androgenetic alopecia is a progressive condition and although the current available treatments are effective in arresting the progression of the disease, they allow only partial regrowth of hair at its best.

Current therapies of female androgenetiC alopeCia and use of fluridil , a novel topiCal antiandrogen

The cosmetic product Eucapil containing 2% fluridil in isopropanol was tested in women with AGA and questionnaires suggest that topical EucAPil lacks systemic effects, an attractive therapeutic alternative in female AGA.

Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men

It is inferred that the therapeutic efficacy is enhanced by combining the two drugs acting on different aetiological aspects of AGA by combining finasteride alone or in combination with minoxidil or ketoconazole.

Efficacy and safety of finasteride therapy for androgenetic alopecia: a systematic review.

Moderate-quality evidence suggests that daily use of oral finasteride increases hair count and improves patient and investigator assessment of hair appearance, while increasing the risk of sexual dysfunction.

Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity.

Evidence‐based treatments for female pattern hair loss: a summary of a Cochrane systematic review

Assessment of the evidence for the effectiveness and safety of the treatments available for female pattern hair loss found that a greater proportion of participants treated with minoxidil reported a moderate increase in their hair regrowth compared with placebo.

Effective treatment of female androgenic alopecia with dutasteride.

Dihydrotestosterone is the main molecule responsible for androgenic alopecia. Finasteride, which reduces transformation of testosterone into dihydrotestosterone and decreases dihydrotestosterone

Novel treatment of female-pattern androgenetic alopecia with injected bimatoprost 0.03% solution.

Critical points to consider in the future of prostaglandin analogs, as well as other therapies being considered for the treatment of female-pattern hair loss, are suggested.

Treatment of hyperandrogenic alopecia in women.

Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Result of a Prospective, Multicenter Study

QoL was more damaged if the patient had severe alopecia, a longer duration of AGA, younger age, had received previous non-medical hair care, and visited the hospital for AGA treatment, showing that AGA could harmfully affect patients' QoL.