Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation.

@article{Chauhan2003AndrogenRO,
  title={Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation.},
  author={Sanjay Chauhan and Ritu Pandey and Jeffrey F Way and Thomas C Sroka and Manolis C. Demetriou and Susan Kunz and Anne E Cress and David W. Mount and Roger L. Miesfeld},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={310 2},
  pages={
          421-32
        }
}
We have developed a cell model to investigate steroid control of differentiation using a subline of HT1080 cells (HT-AR1) that have been engineered to express the human androgen receptor. Dihydrotestosterone (DHT) treatment of HT-AR1 cells induced growth arrest and cytoskeletal reorganization that was associated with the expression of fibronectin and the neuroendocrine markers chromogranin A and neuron-specific enolase. Expression profiling analysis identified the human FERM domain-encoding… CONTINUE READING

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