Androgen regulation of the Pem homeodomain gene in mice and rat Sertoli and epididymal cells.

@article{Sutton1998AndrogenRO,
  title={Androgen regulation of the Pem homeodomain gene in mice and rat Sertoli and epididymal cells.},
  author={Keith A. Sutton and Smarajit Maiti and Walter A. Tribley and Jennifer S. Lindsey and Marvin Lawrence Meistrich and Corazon D. Bucana and Barbara Mortensen Sanborn and David Ralph Joseph and Mike D Griswold and G A Cornwall and Miles F Wilkinson},
  journal={Journal of andrology},
  year={1998},
  volume={19 1},
  pages={
          21-30
        }
}
Although the role of homeodomain transcription factors during embryogenesis is well known, their developmental function in postnatal animals is only beginning to be understood. We examined the regulation and expression pattern of Pem, a homeodomain protein that may regulate androgen-dependent events in the testis and epididymis. Immunohistochemical analysis showed that Pem protein is expressed selectively in the nuclei of Sertoli cells during the androgen-dependent stage of the seminiferous… CONTINUE READING
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