Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP

@article{Rokhlin2005AndrogenRA,
  title={Androgen regulates apoptosis induced by TNFR family ligands via multiple signaling pathways in LNCaP},
  author={Oskar W. Rokhlin and Agshin F. Taghiyev and Natalya V. Guseva and Rebecca A. Glover and Peter M Chumakov and Julia Evgenyevna Kravchenko and Michal Becker Cohen},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={6773-6784}
}
It has been suggested in many studies that combined treatment with chemotherapeutic agents and apoptosis-inducing ligands belonging to TNFR family is a more effective strategy for cancer treatment. However, the role of androgen regulation of TNFR family-induced apoptosis in prostate cancer is poorly understood. In this study, we investigated the dose-dependent effects of androgen on TNF-α and TRAIL-mediated apoptosis in LNCaP. To investigate the interaction between the androgen receptor (AR… CONTINUE READING
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