Androgen receptors in the diabetic rat

  title={Androgen receptors in the diabetic rat},
  author={Marta Tesone and Ricardo Martins de Oliveira-Filho and Liza Valle and J. Carlos Calvo and Jos{\'e} Lino Bara{\~n}ao and Virgilio G. Foglia and Eduardo Hern{\'a}n Charreau},
Male rats rendered diabetic by IV streptozotocin (65mg/kg body weight) were treated with exogenous insulin or testosterone. Charcoal-coated dextran and polyacrylemide gel electrophoresis techniques were employed in studying the characteristics of androgen (R1881) binding to prostate cytosol protein. In comparison with normal (N) rats, the replacement therapy of diabetic (D) animals with insulin (D+I) or testosterone (D+T) was able to restore epididymal weight (N = 0.40 ±0.04 g; D = 0.18 ± 0.02… CONTINUE READING


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Some effects of experimentally-induced diabetes on pituitary-testicular relationships in rats

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