Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting

@article{Antonarakis2016AndrogenRV,
  title={Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting},
  author={Emmanuel S Antonarakis and Andrew James Armstrong and Scott M Dehm and Jun Luo},
  journal={Prostate Cancer and Prostatic Disease},
  year={2016},
  volume={19},
  pages={231-241}
}
While there are myriad mechanisms of primary and acquired resistance to conventional and next-generation hormonal therapies in prostate cancer, the potential role of androgen receptor splice variants (AR-Vs) has recently gained momentum. AR-Vs are abnormally truncated isoforms of the androgen receptor (AR) protein that lack the COOH-terminal domain but retain the NH2-terminal domain and DNA-binding domain and are thus constitutively active even in the absence of ligands. Although multiple… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 104 REFERENCES

Similar Papers

Loading similar papers…