Androgen receptor variant-7: an important predictive biomarker in castrate resistant prostate cancer

@inproceedings{Sartor2015AndrogenRV,
  title={Androgen receptor variant-7: an important predictive biomarker in castrate resistant prostate cancer},
  author={Oliver A Sartor and Yan Dong},
  booktitle={Asian journal of andrology},
  year={2015}
}
The recent manuscript in New England Journal of Medicine by Antonarakis et al. [1] has important clinical implications. This study evaluates mRNA expression of a particular androgen receptor splice variant-7 (AR-V7), in circulating tumor cells (CTCs) from metastatic castrate-resistant prostate cancer (mCRPC) patients receiving enzalutamide or abiraterone. The findings were striking, none of the 18 patients with detectable AR-V7 in CTCs had prostate-specific antigen (PSA) responses. Further, the… CONTINUE READING

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