Androgen receptor splice variants determine taxane sensitivity in prostate cancer.

@article{ThadaniMulero2014AndrogenRS,
  title={Androgen receptor splice variants determine taxane sensitivity in prostate cancer.},
  author={Maria Thadani-Mulero and Luigi Portella and Shihua Sun and Matthew S Sung and Alexandre Matov and Robert L. Vessella and Eva Corey and David M. Nanus and Stephen R. Plymate and Paraskevi Giannakakou},
  journal={Cancer research},
  year={2014},
  volume={74 8},
  pages={2270-2282}
}
Prostate cancer growth depends on androgen receptor signaling. Androgen ablation therapy induces expression of constitutively active androgen receptor splice variants that drive disease progression. Taxanes are a standard of care therapy in castration-resistant prostate cancer (CRPC); however, mechanisms underlying the clinical activity of taxanes are poorly understood. Recent work suggests that the microtubule network of prostate cells is critical for androgen receptor nuclear translocation… CONTINUE READING