Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy

Abstract

Upregulation of constitutively-active androgen receptor splice variants (AR-Vs) has been implicated in AR-driven tumor progression in castration-resistant prostate cancer. To date, functional studies of AR-Vs have been focused mainly on their ability to regulate gene expression independent of the full-length AR (AR-FL). Here, we showed that AR-V7 and… (More)

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Cao2014AndrogenRS, title={Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy}, author={Bo Cao and Yanfeng Qi and Guanyi Zhang and Duo Xu and Yang Zhan and Xavier Alvarez and Zhiyong Guo and Xueqi Fu and Stephen R. Plymate and Oliver A Sartor and Haitao Zhang and Yan Dong}, booktitle={Oncotarget}, year={2014} }