Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells.

@article{Berry2008AndrogenRS,
  title={Androgen receptor signalling in prostate: effects of stromal factors on normal and cancer stem cells.},
  author={P. A. M. Berry and Norman J. Maitland and Anne T Collins},
  journal={Molecular and cellular endocrinology},
  year={2008},
  volume={288 1-2},
  pages={30-7}
}
The prostate gland is the most common site for cancer in males within the developed world. Androgens play a vital role in prostate development, maintenance of tissue function and pathogenesis of prostate disease. The androgen receptor signalling pathway facilitates that role in both the epithelial compartment and in the underlying stroma. Stroma is a key mediator of androgenic effects upon the epithelium and can regulate both the fate of the epithelial stem cell and potentially the initiation… CONTINUE READING