Androgen receptor protein in the androgen-dependent Dunning R-3327 prostate carcinoma.

  title={Androgen receptor protein in the androgen-dependent Dunning R-3327 prostate carcinoma.},
  author={Oscar A. Lea and Frank S. French},
  journal={Cancer research},
  volume={41 2},
The rat prostate carcinoma (Dunning R-3327) contains a relatively high concentration of androgen receptor (80 to 150 fmol/mg cytosol protein). We characterized this receptor for comparison with androgen receptors in normal organs of the rat. Binding of testosterone and dihydrotestosterone was of high affinity (Ka = 2 X 10(9) M). Rates of dissociation were slow (t 1/2 testosterone = 60 hr; t 1/2 dihydrotestosterone = approximately 160 hr). At low ionic strength, the receptor was in an 8S form… CONTINUE READING
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Animal models of hormone - sensitive and - insensitive prostatic adenocarcinomas . Dunning R - 3327 - H , R - 3327 - HI , and R - 3327 - AT

  • T. Isaacs.J., W. D. W. Heston, R. M. Weissman, D. Coffey
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