Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.

@article{Yoshida2013AndrogenRP,
  title={Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.},
  author={Sumiko Yoshida and Ken-ichi Aihara and Yasumasa Ikeda and Yuka Sumitomo-Ueda and Ryoko Uemoto and Kazue Ishikawa and Takayuki Ise and Syusuke Yagi and Takashi Iwase and Yasuhiro Mouri and Matomo Sakari and Takahiro Matsumoto and Ken-ichi Takeyama and Masashi Akaike and Mitsuru Matsumoto and Masataka Sata and Kenneth Walsh and Shigeaki Kato and Toshio Matsumoto},
  journal={Circulation},
  year={2013},
  volume={128 1},
  pages={60-71}
}
BACKGROUND Hypoandrogenemia is associated with an increased risk of ischemic diseases. Because actions of androgens are exerted through androgen receptor (AR) activation, we studied hind-limb ischemia in AR knockout mice to elucidate the role of AR in response to ischemia. METHODS AND RESULTS Both male and female AR knockout mice exhibited impaired blood flow recovery, more cellular apoptosis, and a higher incidence of autoamputation after ischemia. In ex vivo and in vivo angiogenesis studies… CONTINUE READING
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