Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.

@article{Wu2010AndrogenRP,
  title={Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription.},
  author={Ming-Heng Wu and Wen-Lung Ma and Cheng-Lung Hsu and Yuh-Ling Chen and Jing-Hsiung James Ou and Charlotte Kathryn Ryan and Yao-Ching Hung and Shuyuan Yeh and Chawnshang Chang},
  journal={Science translational medicine},
  year={2010},
  volume={2 32},
  pages={
          32ra35
        }
}
Hepatitis B virus (HBV)-induced hepatitis and carcinogen-induced hepatocellular carcinoma (HCC) are associated with serum androgen concentration. However, how androgen or the androgen receptor (AR) contributes to HBV-induced hepatocarcinogenesis remains unclear. We found that hepatic AR promotes HBV-induced hepatocarcinogenesis in HBV transgenic mice that lack AR only in the liver hepatocytes (HBV-L-AR(-/y)). HBV-L-AR(-/y) mice that received a low dose of the carcinogen N'-N'-diethylnitrosamine… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 80 CITATIONS

FILTER CITATIONS BY YEAR

2011
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations

  • Averaged 7 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES

Iloeje; REVEAL-HBV Study Group, Hepatitis B virus DNA levels and outcomes in chronic hepatitis

C. J. Chen, U.H.H.I. Yang
  • B. Hepatology 49,
  • 2009
VIEW 3 EXCERPTS

Similar Papers

Loading similar papers…