Androgen receptor on the move: boarding the microtubule expressway to the nucleus.

@article{ThadaniMulero2012AndrogenRO,
  title={Androgen receptor on the move: boarding the microtubule expressway to the nucleus.},
  author={Maria Thadani-Mulero and David M. Nanus and Paraskevi Giannakakou},
  journal={Cancer research},
  year={2012},
  volume={72 18},
  pages={4611-5}
}
Recent studies have shown that the microtubule-stabilizing drug paclitaxel, which is commonly used for the treatment of prostate cancer, inhibits signaling from the androgen receptor by inhibiting its nuclear accumulation downstream of microtubule stabilization. This mechanism is independent of paclitaxel-induced mitotic arrest and could provide an… CONTINUE READING