Androgen receptor-mediated transcriptional regulation in the absence of direct interaction with a specific DNA element.

@article{Kallio1995AndrogenRT,
  title={Androgen receptor-mediated transcriptional regulation in the absence of direct interaction with a specific DNA element.},
  author={Pasi J Kallio and Hetti Poukka and A-M. Moilanen and Olli A. J{\"a}nne and Jorma J. Palvimo},
  journal={Molecular endocrinology},
  year={1995},
  volume={9 8},
  pages={1017-28}
}
Androgen receptor (AR) brings about a ligand-dependent inhibition of low-affinity neurotrophin receptor (p75) promoter constructs in cultured cells, with the greatest inhibition being achieved with a reporter gene containing 1050 nucleotides (nt) of the promoter. The receptor domain critical for trans-repression localizes to the same region (amino acids 147-296) as that mandatory for transactivation. In contrast to trans-activation, AR does not interact directly with specific DNA elements to… CONTINUE READING

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