Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney.

@article{Quinkler2005AndrogenRR,
  title={Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney.},
  author={Marcus Quinkler and Iwona J. Bujalska and Kirren Kaur and Claire Uchechukwu Onyimba and Sabine Buhner and Wim Van Biesen and Susan V. Hughes and Martin Hewison and Paul Michael. Stewart},
  journal={Hypertension},
  year={2005},
  volume={46 4},
  pages={
          787-98
        }
}
Rodents studies suggest that androgens are involved in sex-specific differences in blood pressure. In humans, there is no difference in blood pressure between boys and girls, but after puberty, blood pressure increases more in men than in women. We investigated androgen-dependent regulation of the alpha-subunit of the epithelial sodium channel (alphaEnaC) in human kidney and in the human renal cell line immortalized human renal proximal tubular cell line (HKC-8). We used microarray technique to… CONTINUE READING

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