Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.

  title={Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer.},
  author={Ana Mar{\'i}a Gonz{\'a}lez-Angulo and Katherine Stemke-Hale and Shana L. Palla and Mark Carey and Roshan Agarwal and Funda Meric-Berstam and Tiffany A. Traina and Clifford A. Hudis and Gabriel N Hortobagyi and William L. Gerald and Gordon B. Mills and Bryan T. J. Hennessy},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={15 7},
PURPOSE To examine the androgen receptor (AR) levels in breast cancer and to assess the impact of AR expression on patient outcomes. EXPERIMENTAL DESIGN Reverse-phase protein arrays were used to measure AR levels and a mass spectroscopy-based approach was used to detect PIK3CA mutations. Means and SDs were generated for AR levels. Linear regression models were used to determine if AR levels differed by tumor subtype and PIK3CA mutation status. Two-sample t tests were used to identify pair… CONTINUE READING


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An integrative genomic and proteomic analysis of PIK 3 CA , PTENand AKTmutations in breast cancer

  • K Stemke-Hale, AM Gonzalez-Angulo, A Lluch
  • Cancer Res
  • 2008

Drug discovery approaches targeting the PI 3 K / Akt pathway in can

  • C Garcia-Echavarria, WR Sellers
  • Oncogene
  • 2008

Quantified pathway inhibition as a pharmacodynamic marker facilitating optimal targeted therapy dosing : proof of principle with theAKT inhibitor perifosine

  • BT Hennessy, Y Lu, E Poradosu
  • Clin Cancer Res
  • 2007

The energy sensing LKB 1AMPK pathway regulates p 27 kip 1 phosphorylation mediating the decision to enter autophagy or apoptosis

  • J Liang, SH Shao, ZX Xu
  • Nat Cell Biol
  • 2007

PIK 3 CAmutation is frequent in class A estrogen receptornegative breast cancer and contributes to the distinct molecular profile

  • AS Doane, ME Moynahan, L Zhang, C Hudis, GeraldWL
  • Breast Cancer ResTreat
  • 2006

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