Androgen receptor in prostate cancer.

@article{Heinlein2004AndrogenRI,
  title={Androgen receptor in prostate cancer.},
  author={Cynthia A. Heinlein and Chawnshang Chang},
  journal={Endocrine reviews},
  year={2004},
  volume={25 2},
  pages={
          276-308
        }
}
The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR). AR remains important in the development and progression of prostate cancer. AR expression is maintained throughout prostate cancer progression, and the majority of androgen-independent or hormone refractory prostate cancers express AR. Mutation of AR, especially mutations that result in a relaxation of AR ligand specificity, may contribute to the progression of prostate… Expand
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References

SHOWING 1-10 OF 435 REFERENCES
Contribution of the Androgen Receptor to Prostate Cancer Predisposition and Progression
TLDR
The recognition of the AR-signaling axis represents a paradigm shift in the understanding of the molecular mechanisms involved in progression of prostate cancer, and provides insight into novel AR-targeted therapies which ultimately may be more effective than current forms of androgen ablation. Expand
The androgen receptor gene and its influence on the development and progression of prostate cancer
TLDR
Gene amplification and somatic mutations, coupled with the fact that various growth factors have been shown to stimulate androgen receptor activity independently of androgens, may enable prostate cancer cells to grow despite testicular‐androgen ablation. Expand
Collocation of androgen receptor gene mutations in prostate cancer.
TLDR
Missense mutations in the AR gene identified in prostate cancer that collocate to discrete regions of the receptor contribute to altered androgen signaling and provide a potential mechanism to explain the reemergence of tumor growth during the course of hormone ablation therapies. Expand
Androgen receptor signaling in androgen-refractory prostate cancer.
TLDR
This review seeks to identify specific molecular events that may be linked directly to the progression to androgen-refractory prostate cancer and identifies mechanisms that appear to involve the androgen receptor (AR). Expand
SMAD 3 Represses Androgen Receptor-mediated Transcription 1
The androgen-signaling pathway is important in the growth and progression of prostate cancer. Androgen ablation therapy, which may result in programmed cell death, is often used to treat advancedExpand
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.
TLDR
Functional studies of two of the mutant androgen receptors demonstrated that they could be activated by progesterone and estrogen, and may provide a selective growth advantage after androgen ablation. Expand
A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.
TLDR
A majority of recurrent prostate cancers express high levels of the androgen receptor and two nuclear receptor coactivators, transcriptional intermediary factor 2 and steroid receptors coactivator 1, and this work provides a molecular basis for this activation and suggests a general mechanism for recurrent prostate cancer growth. Expand
Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.
TLDR
The results suggest that AR is transcriptionally active in recurrent CaP and can increase cell proliferation at the low circulating levels of androgen reported in castrated men. Expand
Differential Regulation of Androgen and Glucocorticoid Receptors by Retinoblastoma Protein*
TLDR
It is found that the level of pRB in cells controls AR activity and the AR has a novel requirement for pRB raising the possibility that the growth promoting activity of AR is due to its direct interaction with pRB. Expand
Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
TLDR
The data indicate that AR gene mutations occur commonly in advanced prostate cancers prior to endocrine treatment of disease and may contribute to altered androgen responsiveness of the tumors. Expand
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