Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids.

@article{Holdcraft2003AndrogenRF,
  title={Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids.},
  author={Robert W. Holdcraft and Robert E Braun},
  journal={Development},
  year={2003},
  volume={131 2},
  pages={
          459-67
        }
}
Androgen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement is thought to be mediated by Sertoli cells and its genetic and pharmacological disruption is manifested in spermatocytes as meiotic arrest. Through studies of a hypomorphic and conditional allele of the androgen receptor (Ar) gene, we have uncovered a dual post-meiotic requirement for androgen receptor… CONTINUE READING

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