Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit.

@article{OHara2011AndrogenRE,
  title={Androgen receptor expression in the caput epididymal epithelium is essential for development of the initial segment and epididymal spermatozoa transit.},
  author={Laura O'Hara and Michelle Welsh and Philippa T. K. Saunders and Lee B. Smith},
  journal={Endocrinology},
  year={2011},
  volume={152 2},
  pages={718-29}
}
The epididymis plays an essential role in male fertility, and disruption of epididymal function can lead to obstructive azoospermia. Formation and function of the epididymis is androgen-dependent. The androgen receptor (AR) is expressed in both the stromal and epithelial compartments of the epididymis, and androgen action mediated via stromal cells is vital for its normal development and function. However the impact of epithelial specific AR-dependent signaling in the epididymis remains… CONTINUE READING
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