Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes.

@article{Gregory1998AndrogenRE,
  title={Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes.},
  author={Christopher William Gregory and Katherine G Hamil and Dongkyoon Kim and Susan Hlesciak Hall and Thomas G. Pretlow and James L. Mohler and Frank S. French},
  journal={Cancer research},
  year={1998},
  volume={58 24},
  pages={
          5718-24
        }
}
The human prostate cancer (CaP) xenograft, CWR22, mimics human CaP. CWR22 grows in testosterone-stimulated nude mice, regresses after castration, and recurs after 5-6 months in the absence of testicular androgen. Like human CaP that recurs during androgen deprivation therapy, the recurrent CWR22 expresses high levels of androgen receptor (AR). Immunohistochemical, Western, and Northern blot analyses demonstrated that AR expression in the androgen-independent CWR22 is similar to AR expression in… CONTINUE READING

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