Androgen receptor and androgen-dependent gene expression in lung.

  title={Androgen receptor and androgen-dependent gene expression in lung.},
  author={Laura Mikkonen and P{\"a}ivi Pihlajamaa and Biswajyoti Sahu and Fu-ping Zhang and Olli A. J{\"a}nne},
  journal={Molecular and cellular endocrinology},
  volume={317 1-2},
The androgen receptor (AR) mediates the effects of male sex steroids. There are major sex differences in lung development and pathologies, including lung cancer. In this report, we show that Ar is mainly expressed in type II pneumocytes and the bronchial epithelium of murine lung and that androgen treatment increases AR protein levels in lung cells. Androgen administration altered significantly murine lung gene expression profiles; for example, by up-regulating transcripts involved in oxygen… CONTINUE READING
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