Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells.

@article{Makkonen2011AndrogenRA,
  title={Androgen receptor amplification is reflected in the transcriptional responses of Vertebral-Cancer of the Prostate cells.},
  author={H. Makkonen and Miia Kauhanen and Tiina J{\"a}{\"a}skel{\"a}inen and Jorma J. Palvimo},
  journal={Molecular and cellular endocrinology},
  year={2011},
  volume={331 1},
  pages={57-65}
}
Androgen receptor (AR) is overexpressed in a majority of castration-resistant prostate cancers, but most of the cell model studies addressing AR function have been conducted in LNCaP prostate cancer cells expressing unamplified AR levels. Here, we have compared the responses of various types of AR ligands towards a pattern of AR target genes and chromatin binding sites in Vertebral-Cancer of the Prostate (VCaP) cells and LNCaP cells. In keeping with the AR gene amplification in VCaP cells, our… CONTINUE READING
20 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…