Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation.

@article{Russell2015AndrogenRA,
  title={Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation.},
  author={Patricia K. Russell and Michele V. Clarke and Karey Y Cheong and Paul H. Anderson and Howard A. Morris and Kristine M. Wiren and Jeffrey Zajac and Rachel A. Davey},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2015},
  volume={30 5},
  pages={
          809-23
        }
}
Androgen action via the androgen receptor (AR) is essential for normal skeletal growth and bone maintenance post-puberty in males; however, the molecular and cellular mechanisms by which androgens exert their actions in osteoblasts remains relatively unexplored in vivo. To identify autonomous AR actions in osteoblasts independent of AR signaling in other tissues, we compared the extent to which the bone phenotype of the Global-ARKO mouse was restored by replacing the AR in osteoblasts… CONTINUE READING

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