Androgen receptor CAG and GGC polymorphisms in Mediterraneans: repeat dynamics and population relationships

@article{Esteban2006AndrogenRC,
  title={Androgen receptor CAG and GGC polymorphisms in Mediterraneans: repeat dynamics and population relationships},
  author={Esther Esteban and Nat{\`a}lia Rod{\'o}n and Marc Via and Emili Gonz{\'a}lez-P{\'e}rez and Josep Maria Santamaria and Jean Michel Dugoujon and Farha El Chennawi and Mohamed Melhaoui and Mohamed Cherkaoui and Giuseppe Vona and Nourdin Harich and Pedro Moral},
  journal={Journal of Human Genetics},
  year={2006},
  volume={51},
  pages={129-136}
}
AbstractMicrosatellite variation (CAG and GGC repeats) of the androgen receptor (AR) gene shows remarkable differences among African and non-African populations. In vitro studies have demonstrated an inverse relationship between the length of both microsatellites and AR activity. This fact may explain the observed association of the AR gene with prostate cancer and the strong ethnic differences in the incidence of this cancer. CAG and GGC genetic variation has been tested in a large set of… CONTINUE READING

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