Androgen priming and chemotherapy in advanced prostate cancer : evaluation of determinants of clinical outcome

@inproceedings{2015AndrogenPA,
  title={Androgen priming and chemotherapy in advanced prostate cancer : evaluation of determinants of clinical outcome},
  author={},
  year={2015}
}
  • Published 2015
We conducted a randomized clinical trial in men with stage D2 prostate cancer to test whether androgen priming potentiates the efficacy of cytotoxic chemotherapy. Eighty-five men with progressive prostate cancer refractory to orchiectomy were treated continuously with aminoglutethimide and hydrocortisone to lower adrenal androgen secretion and were administered cyclic intravenous (IV) chemotherapy. The patients were randomized to receive either androgen priming or no additional treatment for… CONTINUE READING