Androgen metabolism in men receiving finasteride before prostatectomy.

  title={Androgen metabolism in men receiving finasteride before prostatectomy.},
  author={Richard W. Norman and K E Coakes and Andrew S Wright and Roger S Rittmaster},
  journal={The Journal of urology},
  volume={150 5 Pt 2},
Oral administration of finasteride, a 5 alpha-reductase inhibitor, affects intraprostatic androgens by suppressing dihydrotestosterone and increasing testosterone. This study was designed to determine the correlation of these effects of finasteride with changes in serum dihydrotestosterone, testosterone and androstanediol glucuronide. In a double blind, placebo-controlled study, 27 men with symptomatic benign prostatic hyperplasia were treated with placebo or 1 or 5 mg. per day finasteride for… CONTINUE READING
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