Androgen metabolism in adipose tissue: Recent advances

  title={Androgen metabolism in adipose tissue: Recent advances},
  author={Karine Blouin and Alain Veilleux and Van Luu-The and Andr{\'e} Tchernof},
  journal={Molecular and Cellular Endocrinology},
Androgens modulate adipocyte function and affect the size of adipose tissue compartments in humans. Aldo-keto reductase 1C (AKR1C) enzymes, especially AKR1C2 and AKR1C3, through local synthesis and inactivation of androgens, may be involved in the fine regulation of androgen availability in adipose tissue. This review article summarizes recent findings on androgen metabolism in adipose tissue. Primary culture models and whole tissue specimens of human adipose tissue obtained from the abdominal… CONTINUE READING
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