Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension.

  title={Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension.},
  author={Kiyoshi Nakagawa and Jackleen S. Marji and Michal L Schwartzman and Michael R. Waterman and Jorge H. Capdevila},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={284 4},
  • K. NakagawaJ. Marji J. Capdevila
  • Published 1 April 2003
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
Hypertension is a leading cause of cardiovascular, cerebral, and renal disease morbidity and mortality, and epidemiological evidence suggests a role for sex-dependent mechanisms in the pathophysiology of hypertension. We show here that treatment of rats with 5alpha-dihydrotestosterone increases the activity of the kidney arachidonate omega/omega-1 hydroxylase and the biosynthesis of 20-HETE (165 and 177% of control untreated male and female rats, respectively) and raises the systolic blood… 

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