Androgen-mediated improvem ent of body composition and muscle function involves a novel early transcriptional program including IGF 1 , mechano growth factor , and induction of b-catenin

@inproceedings{Gentile2009AndrogenmediatedIE,
  title={Androgen-mediated improvem ent of body composition and muscle function involves a novel early transcriptional program including IGF 1 , mechano growth factor , and induction of b-catenin},
  author={Michael A. Gentile and Pascale V. Nantermet and Robert Lewis Vogel and Robert S Phillips and Daniel J. Holder and Paul Hodor and Chun Min Cheng and Hongyue Dai and Leonard P. Freedman and William J. Ray},
  year={2009}
}
Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, we demonstrate that aged castrated rats develop increased fat mass, reduced muscle mass and strength, and lower bone mass. Treatment with testosterone or 5a-dihydrotestosterone (DHT… CONTINUE READING

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