Androgen-mediated immune function is altered by the apolipoprotein E gene.

@article{Brown2007AndrogenmediatedIF,
  title={Androgen-mediated immune function is altered by the apolipoprotein E gene.},
  author={Candice M Brown and Qing Xu and Nobutaka Okhubo and Michael P Vitek and Carol A. Colton},
  journal={Endocrinology},
  year={2007},
  volume={148 7},
  pages={3383-90}
}
Androgens, like estrogens, have been linked to neuroprotective effects in the brain and to the improvement of cognitive function. Part of this effect may be due to the action of androgens on the innate immune response. We have examined the action of dihydrotestosterone (DHT) and testosterone on immune activation in primary cultures of microglia, the central nervous system macrophage. Our data indicate that DHT acts as an antiinflammatory agent and depresses both nitric oxide and TNFalpha… CONTINUE READING