Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer

@article{Ashikari2017AndrogenIG,
  title={Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer},
  author={Daisaku Ashikari and Kaoru Takayama and Tomoaki Tanaka and Yutaka Suzuki and Daisuke Obinata and Taku Fujimura and Tomohiko Urano and S Takahashi and Satoshi Inoue},
  journal={Oncogene},
  year={2017},
  volume={36},
  pages={6272-6281}
}
The androgen receptor (AR) has a central role in prostate cancer progression, particularly treatment-resistance disease including castration-resistant prostate cancer. Loss of the p53 tumor suppressor, a nuclear transcription factor, is also known to contribute to prostate malignancy. Here we report that p53 is translocated to the cytoplasm by androgen-mediated induction of G3BP2, a newly described direct target gene of AR. G3BP2 induces both cell cycle progression and blocks apoptosis… CONTINUE READING
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