Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase.

Abstract

Testosterone (T), the major circulating androgen, must be converted to dihydrotestosterone (DHT) by the enzyme 5alpha-reductase (5alpha-R) to be maximally active in the prostate. The present study was designed to determine the relative potency of T and DHT on regrowth of the involuted prostate and to elucidate the role of 5alpha-R in the growing prostate… (More)

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@article{Wright1999AndrogeninducedRI, title={Androgen-induced regrowth in the castrated rat ventral prostate: role of 5alpha-reductase.}, author={A Stuart Wright and Robert C Douglas and Lynn N. Thomas and Catherine B. Lazier and Roger S. Rittmaster}, journal={Endocrinology}, year={1999}, volume={140 10}, pages={4509-15} }