Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.

  title={Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.},
  author={Raanan Berger and Phillip G. Febbo and Pradip K. Majumder and Jean J. Zhao and Shayan Mukherjee and Sabina Signoretti and Kayleen T Campbell and William R Sellers and Thomas M Roberts and Massimo F. Loda and Todd R. Golub and William C. Hahn},
  journal={Cancer research},
  volume={64 24},
Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate cancer development remains enigmatic. Using a series of genetically defined immortalized and tumorigenic human prostate epithelial cells, we found that introduction of the androgen receptor induced differentiation of transformed prostate epithelial cells to a luminal phenotype reminiscent of organ-confined prostate cancer when placed in… CONTINUE READING