Androgen independence of primary epithelial cultures of the prostate is associated with a down-regulation of androgen receptor gene expression.


BACKGROUND Epithelial cells cultured from prostatic acini do not demonstrate significant (P > 0.05) growth response to the testosterone metabolite dihydrotestosterone (DHT) at concentrations of 0.001-10.0 nM. In addition, the nonsteroidal antiandrogen hydroxyflutamide (HO-F) does not influence primary epithelial cell proliferation in this concentration… (More)


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