Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells.

@article{Krongrad1991AndrogenIA,
  title={Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells.},
  author={Arnon Krongrad and Carol M. Wilson and J Douglas Wilson and Dr. Richard M. Allman and Michael J. McPhaul},
  journal={Molecular and cellular endocrinology},
  year={1991},
  volume={76 1-3},
  pages={79-88}
}
We have examined the effect of androgen treatment on androgen receptor mRNA and protein expression in the LNCaP human prostate carcinoma cell line. Incubation with androgen caused a decrease in cellular androgen receptor mRNA content that was concentration and time dependent. Maximal suppression to approximately 35% of control level was observed after 49 h of exposure to androgen. By contrast, incubation of LNCaP cells with androgen resulted in a 2-fold increase in the cellular content of… CONTINUE READING

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