Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?

@article{Abbott2005AndrogenEF,
  title={Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?},
  author={David H. Abbott and Deborah K. Barnett and Cristin M. Bruns and Daniel A Dumesic},
  journal={Human reproduction update},
  year={2005},
  volume={11 4},
  pages={
          357-74
        }
}
The aetiology of polycystic ovary syndrome (PCOS) remains unknown. This familial syndrome is prevalent among reproductive-aged women and its inheritance indicates a dominant regulatory gene with incomplete penetrance. However, promising candidate genes have proven unreliable as markers for the PCOS phenotype. This lack of genetic linkage may represent both extreme heterogeneity of PCOS and difficulty in establishing a universally accepted PCOS diagnosis. Nevertheless, hyperandrogenism is one of… CONTINUE READING

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