Androgen-estrogen synergy in rat levator ani muscle: glucose-6-phosphate dehydrogenase

  title={Androgen-estrogen synergy in rat levator ani muscle: glucose-6-phosphate dehydrogenase},
  author={Stephen R. Max},
  journal={Molecular and Cellular Endocrinology},
  • S. R. Max
  • Published 31 December 1984
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
Androgen-estrogen synergy in the regulation of energy metabolism in epididymis and vas deferens of rhesus monkey.
The results suggest that circulating estrogen in male has a physiological role and acts synergistically with androgen in regulating accessory sex organ function.
Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway.
  • Rui Peng, W. Dai, Yan Li
  • Biology, Medicine
    Toxicology in vitro : an international journal published in association with BIBRA
  • 2018
Testosterone: a metabolic hormone in health and disease.
Current knowledge of the metabolic actions of testosterone and how testosterone deficiency contributes to the clinical disease states of obesity, MetS and type 2 diabetes and the role of testosterone replacement are discussed.
Testosterone and obesity
  • D. Kelly, T. Jones
  • Biology, Medicine
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2015
Testosterone replacement therapy demonstrates beneficial effects on measures of obesity that are partially explained by both direct metabolic actions on adipose and muscle and also potentially by increasing motivation, vigour and energy allowing obese individuals to engage in more active lifestyles.
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
Biochemical evidence indicates that testosterone is involved in promoting glucose utilization by stimulating glucose uptake, glycolysis and mitochondrial oxidative phosphorylation, and also involved in lipid homeostasis in major insulin-responsive target tissues, such as liver, adipose tissue and skeletal muscle.
Hormonal control of muscle growth
Results with purified proteins do not support the view that mitogens block myoblast differentiation; transforming growth factor‐beta and interferon are nonmitogenic proteins that inhibit differentiation, insulin‐like growth factors are mitogens that stimulate differentiation, and fibroblast growth factor is the only purified mitogen that inhibits differentiation.
Sexual differences and steroid-induced changes in metabolic activity in toadfish sonic muscle.
It is concluded that toadfish sonic muscle can be classified as fast- twitch oxidative glycolytic or fast-twitch fatigue resistant, providing the male with the capacity for increased sound production.
The Expression of Hormone Receptors as a Gateway toward Understanding Endocrine Actions in Female Pelvic Floor Muscles.
Hormone receptor expression is the cornerstone in some hormone-based therapies, which require further detailed studies on the distribution of receptors in particular pelvic floor muscles, as well as their association with muscle effectors, involved in the alterations relevant for understanding pelvic floor disorders.


Aromatization of androgens to estrogens mediates increased activity of glucose 6-phosphate dehydrogenase in rat levator ani muscle.
A direct effect of estrogen on striated muscle is demonstrated and appears to be mediated by conversion of testosterone to estradiol.
The mechanism of androgen and estrogen synergism in the chick oviduct. Estrogen-modulated changes in cytoplasmic androgen receptor concentrations.
It is suggested that estrogen treatment is required for the induction and maintenance of the androgen cytoplasmic receptor and that the ability of androgens to modulate magnum growth and ovalbumin mRNA levels correlates with the concentration of this receptor.
Regulation of the androgen and glucocorticoid receptors in rat and mouse skeletal muscle cytosol.
The concentrations of androgen and glucocorticoid receptors in rat skeletal muscle are regulated at least by the testes, and the presence of androgens receptors in skeletal muscle from Tfm mice is surprising and may motivate a reinvestigation of the regulation ofandrogen receptors in Tfm animals.
Characterization of the cytosolic estrogen receptor in rat skeletal muscle.
  • E. Dahlberg
  • Biology, Chemistry
    Biochimica et biophysica acta
  • 1982
Aromatization of androgens by muscle and adipose tissue in vivo.
In seven men the mean +/- SE value for the fractional conversion of androstene tissue was 0.0007 +/-0.0001 for muscle and 0.0012 +/- 0.0002 for adipose tissue, both of these values were significantly less than the respective values of and Frostenedione aromatization to estrone.
The pentose phosphate pathway in regenerating skeletal muscle.
Histochemical analysis localized glucose 6-phosphate dehydrogenase activity within muscle fibres of control and Marcaine-treated muscles, suggesting a requirement for synthesis of protein and RNA.
Effects of estradiol and progesterone on plasma gonadotropins, prolactin, and LHRH in specific brain areas of ovariectomized rats.
Higher plasma E2 concentrations induced by the 150 �g/ml E2 capsule were correlated with higher LHRH concentraions in the median eminence concomitant with a parallel trend in some of the anterior brain areas: MPN), SPN, SPN (P<0.06), and RCA (P <0.03).
Estrogen Modulates Neural Control of Muscle Glucose 6‐Phosphate Dehydrogenase
It is reported that the effect of denervation on glucose 6‐phosphate dehydrogenase activity is modified by variations in endogenous estradiol during the estrous cycle.