Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause.

@article{Sherwin1985AndrogenES,
  title={Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause.},
  author={Barbara Brender Sherwin and Morrie M. Gelfand and William Brender},
  journal={Psychosomatic Medicine},
  year={1985},
  volume={47},
  pages={339–351}
}
&NA; Various parameters of sexual functioning were assessed in a prospective, crossover investigation of 53 surgically menopausal women. Patients randomly received either an estrogen‐androgen combined preparation, an estrogen‐alone drug, an androgen‐alone drug, or a placebo. Also included were a group of women who had undergone hysterectomy and whose ovaries had been left intact. Two treatment phases, each of 3 months' duration, were separated by an intervening placebo month. Additionally… 
Increasing women's sexual desire: The comparative effectiveness of estrogens and androgens
The effects of postmenopausal hormone therapies on female sexual functioning: a review of double-blind, randomized controlled trials
TLDR
Double-blind randomized controlled trials of estrogen and/or testosterone on sexual function among natural or surgical menopause in women are reviewed and whether specific serum hormone levels are related to sexual functioning and how these group effects apply to individual women are unclear.
Testosterone therapy in women: a review
TLDR
The results of these trials suggest that testosterone therapy in the low-dose regimens is efficacious for the treatment of Women's Sexual Interest and Desire Disorder in postmenopausal women who are adequately estrogenized.
Testosterone therapy for sexual dysfunction in postmenopausal women
  • Z. Hubayter, J. Simon
  • Medicine, Biology
    Climacteric : the journal of the International Menopause Society
  • 2008
TLDR
Exogenous testosterone treatment provides a rational therapeutic alternative to consider in women whose hypoactive sexual desire disorder negatively affects their quality of life and who have no biologic or psychosocial causes not related to decreased androgen levels for their sexual disorder.
Effects of hormone treatment on sexual functioning in postmenopausal women
TLDR
If pharmacotherapy is indicated, tibolone should be considered as a first line treatment option for postmenopausal women with sexual dysfunction as its efficacy and medium to long term tolerability & safety is now sufficiently established.
Testosterone patch increases sexual activity and desire in surgically menopausal women with hypoactive sexual desire disorder.
TLDR
In the Intimate SM 1 study, the testosterone patch improved sexual function and decreased distress in surgically menopausal women with HSDD and was well tolerated in this trial.
Androgens and sexuality.
Testosterone treatment for hypoactive sexual desire disorder in postmenopausal women.
TLDR
The transdermal testosterone patch is an effective treatment for hypoactive sexual desire disorder in surgically postmenopausal women receiving concomitant estrogen therapy and has a favorable safety profile.
Testosterone Patch for Low Sexual Desire in Surgically Menopausal Women: A Randomized Trial
TLDR
In surgically menopausal women with hypoactive sexual desire disorder, a 300 μg/d testosterone patch significantly increased satisfying sexual activity and sexual desire, while decreasing personal distress, and was well tolerated through up to 24 weeks of use.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Hormone replacement therapy and sexuality in women.
TLDR
This chapter reviews the available evidence, focuses on the following: animal studies (nonprimates, primates, mechanism of action, and methodological considerations); the effects of depletion of ovarian hormones on human sexuality; the effect of hormone replacement therapies (clinical trial); and clinical implications.
The nature of androgen action on male sexuality: a combined laboratory-self-report study on hypogonadal men.
TLDR
The data and previous findings lead to the conclusion that the major androgen action on male sexuality involves libido factors (i.e. sexual motivation/interest).
Effects of parenteral administration of estrogen and androgen on plasma hormone levels and hot flushes in the surgical menopause.
Mood, Sexuality, Hormones, and the Menstrual Cycle. III. Sexuality and the Role of Androgens
&NA; Sexual interest and activity at different stages of the menstrual cycle was recorded by 55 women with normal ovulatory cycles. In women with marked cyclical mood change, there was an associated
The Relationship of Plasma Estradiol Level to Sexual Behavior in Young Women
The role of estrogens in human female sexual behavior has been surrounded by controversy for the past half century. In their pioneering psychoendocrine study of the human menstrual cycle, Benedek and
The hormonal activity of the postmenopausal ovary.
  • A. Vermeulen
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 1976
TLDR
It is concluded that the adrenal cortex is almost the exclusive source of plasma estradiol, estrone, progesterone, and 17OH progester one and the most important source of Plasma dehydroepiandrosterone and that hCG stimulation with 5000 IU daily for 3 days, hardly influences steroid secretion by postmenopausal ovaries.
Psychoendocrinology of the Menstrual Cycle: II. The Relationship Between Enjoyment of Activities, Moods, and Reproductive Hormones
TLDR
Results showed that in this sample of healthy women there was no relationship between mood states or enjoyment of activities and phase of the menstrual cycle, andno relationship between these psychological states and absolute levels of the reproductive hormones estradiol and progesterone.
Combination of Hormonal and Psychological Treatment for Female Sexual Unresponsiveness: a Comparative Study
TLDR
Those receiving testosterone did significantly better on a number of behavioural and attitudinal measures than the diazepam group and further work is needed to establish the indications for testosterone therapy for unresponsive women.
Oestrogen therapy and the menopausal syndrome.
TLDR
The improvement in memory and reduction of anxiety in these patients suggest that oestrogens have a direct tonic effect on the mental state which is independent of vasomotor symptoms, and it is likely that the cumulative effect of these small improvements results in an overall enhancement of well-being.
...
1
2
3
...