Androgen effects mediated by estrogen receptor in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.

@article{Garcia1978AndrogenEM,
  title={Androgen effects mediated by estrogen receptor in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors.},
  author={Marcel Garcia and Henri Rochefort},
  journal={Cancer research},
  year={1978},
  volume={38 11 Pt 1},
  pages={3922-9}
}
To improve our understanding of the effects of androgens on the induction and growth of mammary tumors, the interaction of androgen on the estrogen receptor (ER) has been evaluated in the 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor. In vitro competitive experiments have shown that androgens interact on ER with a low affinity but have a good stereospecificity for C,9 steroids bearing a 170and/or 3/3-hydroxyl group. The administration of one dose ( -20 mg) of 5a-dihydrotestosterone… CONTINUE READING
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