Androgen deprivation therapy for prostate cancer: Current status and future prospects

@article{Miyamoto2004AndrogenDT,
  title={Androgen deprivation therapy for prostate cancer: Current status and future prospects},
  author={H. Miyamoto and E. Messing and C. Chang},
  journal={The Prostate},
  year={2004},
  volume={61}
}
  • H. Miyamoto, E. Messing, C. Chang
  • Published 2004
  • Medicine
  • The Prostate
  • Androgens play a major role in promoting the development and progression of prostate cancer. As a result, androgen ablation or blockade of androgen action through the androgen receptor (AR) has been the cornerstone of treatment of advanced prostate cancer. Different strategies involving this hormonal therapy produce a significant clinical response in most of the patients, but most responders eventually lose dependency, resulting in mortality. Thus, whether hormonal therapy contributes to the… CONTINUE READING
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    References

    SHOWING 1-10 OF 222 REFERENCES
    Transition to androgen-independence in prostate cancer
    • 100
    Androgen receptor signaling in androgen-refractory prostate cancer.
    • 534
    • PDF
    Chemotherapy for prostate cancer.
    • 88
    The biology of hormone refractory prostate cancer. Why does it develop?
    • J. Isaacs
    • Medicine
    • The Urologic clinics of North America
    • 1999
    • 273