Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion

@article{Harris2009AndrogenDT,
  title={Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion},
  author={William Proctor Harris and Elahe A. Mostaghel and Peter S. Nelson and Bruce Montgomery},
  journal={Nature Clinical Practice Urology},
  year={2009},
  volume={6},
  pages={76-85}
}
Androgen deprivation therapy remains a critical component of treatment for men with advanced prostate cancer, and data support its use in metastatic disease and in conjunction with surgery or radiation in specific settings. Alternatives to standard androgen deprivation therapy, such as intermittent androgen suppression and estrogen therapy, hold the potential to improve toxicity profiles while maintaining clinical benefit. Current androgen deprivation strategies seem to incompletely suppress… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
190 Citations
75 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 190 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 75 references

The role of testosterone in the pathogenesis of prostate cancer

  • I Takashi
  • Int J Urol
  • 2008
Highly Influential
10 Excerpts

Androgen receptor inactivation contributes to antitumor efficacy of 17 αhydroxylase / 17 , 20lyase inhibitor 3 βhydroxy17( 1 Hbenzimidazole1yl ) androsta5 , 16diene in prostate cancer

  • EA Mostaghel, PS Nelson
  • Mol Cancer Ther
  • 2008

Five years survival

  • FM Calais da Silva
  • [abstract
  • 2008

Five years survival and risk of death in a phase III study of intermittent monotherapy versus continuous combined androgen deprivation [ abstract # 16034 ]

  • U Tunn
  • J Clin Oncology
  • 2008

Similar Papers

Loading similar papers…