Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells.

@article{Tso2000AndrogenDI,
  title={Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells.},
  author={C L Tso and William H. Mcbride and Jing Sun and Bina S Patel and Kenneth Hing-Sum Tsui and Sun H Paik and Barbara Jennifer Gitlitz and Randy R Caliliw and Arndt van Ophoven and L Wu and Jean B. Dekernion and Arie S. Belldegrun},
  journal={Cancer journal},
  year={2000},
  volume={6 4},
  pages={220-33}
}
PURPOSE The mechanism of progression of human prostate cancer (CaP) cells under androgen ablation therapy remains unclear. To study the alternative pathways of CaP cell growth under conditions of androgen deprivation, androgen-independent CaP variants were selected and expanded from an androgen-dependent CaP line via an in vitro androgen deprivation treatment. Cellular and molecular properties of these androgen-independent variants were characterized both in vitro and in vivo and compared with… CONTINUE READING