Androgen deprivation induces rapid involution and recovery of human prostate vasculature.

@article{Godoy2011AndrogenDI,
  title={Androgen deprivation induces rapid involution and recovery of human prostate vasculature.},
  author={A. P. Rebolledo Godoy and Viviana P. Montecinos and Danny R. Gray and Paula C. Sotomayor and Jeffrey M. Yau and R. Robert Vethanayagam and Swaroop S Singh and James L. Mohler and G. Jason Smith},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 2},
  pages={E263-75}
}
The response of the prostate tissue microenvironment to androgen deprivation (AD) represents a critical component in the treatment of benign prostatic hyperplasia and prostate cancer (CaP). Primary xenografts of human benign and CaP tissue transplanted to immunocompromized SCID mice were used to characterize the response of the prostate vasculature during the initial 14 days of AD. Microvessel density and vascular lumen diameter in the prostate xenografts decreased rapidly after AD, reached a… CONTINUE READING