Androgen deprivation and radiation therapy: sequencing studies using the Shionogi in vivo tumor system.

@article{Zietman1997AndrogenDA,
  title={Androgen deprivation and radiation therapy: sequencing studies using the Shionogi in vivo tumor system.},
  author={Anthony Laurence Zietman and Elizabeth Prince and Bruce M Nakfoor and Jessica J Park},
  journal={International journal of radiation oncology, biology, physics},
  year={1997},
  volume={38 5},
  pages={1067-70}
}
PURPOSE To test the relative effect of neoadjuvant and adjuvant androgen deprivation on the radiation response of an androgen dependent tumor. METHODS AND MATERIALS The transplantable, androgen dependent, Shionogi adenocarcinoma was grown as allografts in the hind limbs of NCr/Sed (nu/nu) athymic nude mice. Bilateral orchiectomy was the chosen form of androgen deprivation. Groups of tumors were irradiated to graded tumor doses and then studied for durable tumor control. The radiation response… CONTINUE READING
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