Androgen dependent regulation of bacillus Calmette-Guerin induced interleukin-6 expression in human transitional carcinoma cell lines.

@article{Chen2003AndrogenDR,
  title={Androgen dependent regulation of bacillus Calmette-Guerin induced interleukin-6 expression in human transitional carcinoma cell lines.},
  author={Fanghong Chen and Peter Langenstroer and GuangJian Zhang and Yoshiki Iwamoto and William A. See},
  journal={The Journal of urology},
  year={2003},
  volume={170 5},
  pages={
          2009-13
        }
}
PURPOSE Autocrine expression of interleukin (IL)-6 by transitional cell carcinoma (TCC) in response to bacillus Calmette-Guerin (BCG) may have an important role in promoting BCG adherence to TCC and consequently in BCG treatment efficacy. IL-6 expression in response to BCG requires nuclear factor (NF)-kappaB mediated signal transduction. We evaluated the influence of androgens on BCG induced, NF-kappaB mediated IL-6 expression. MATERIALS AND METHODS Reverse transcriptase-polymerase chain… CONTINUE READING

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