Androgen-controlled specific gene expression in neuroblastoma cells

  title={Androgen-controlled specific gene expression in neuroblastoma cells},
  author={P. Yerramilli-Rao and O. Garofalo and Sharon Whatley and Peter Nigel Leigh and J. -M. Gallo},
  journal={Journal of the Neurological Sciences},
In Kennedy's syndrome, a mutation in the androgen receptor (AR) gene leads to sensory and lower motor neurone degeneration, therefore genes that are regulated by androgens in neurones may be important in the process of motor neurone cell death. The aim of this study was to identify androgen-inducible genes in the human neuroblastoma cell line SH-SY5Y. We have shown that SH-SY5Y cells expressed the AR by Northern blot analysis using a 32P-labelled probe derived from a human AR cDNA. Differential… CONTINUE READING