Androgen binding in peripheral tissues of fetal rhesus macaques: effects of androgen metabolism in liver.

@article{Abdelgadir1990AndrogenBI,
  title={Androgen binding in peripheral tissues of fetal rhesus macaques: effects of androgen metabolism in liver.},
  author={Salah E. Abdelgadir and Patty Connolly and John A. Resko},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1990},
  volume={37 4},
  pages={545-51}
}
In rhesus monkeys sexual differentiation of the brain and reproductive tract (RT) is androgen-dependent. Presumably these effects are mediated through the androgen receptor (AR). The AR has not been characterized in fetal tissues such as liver, kidney, heart, spinal cord and RT in this species. We characterized AR binding using [3H]R1881 as the ligand in cytosols from tissues obtained on days 100-138 of gestation. Scatchard analyses revealed a single, saturable, high affinity AR in liver… CONTINUE READING