Androgen and glucocorticoid receptors interact with insulin degrading enzyme.

@article{Kupfer1994AndrogenAG,
  title={Androgen and glucocorticoid receptors interact with insulin degrading enzyme.},
  author={Stuart R. Kupfer and Elizabeth M. Wilson and Frank S. French},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 32},
  pages={20622-8}
}
We recently identified a protein, designated receptor accessory factor (RAF), that interacts directly with and enhances the DNA binding of androgen (AR) and glucocorticoid (GR) receptor peptide fragments. To determine its identity, RAF was purified from HeLa cell extracts by anion-exchange and DNA affinity chromatography. RAF activity co-purified with a 110-kDa protein, the partial amino acid sequence of which shares 97.5% identity with insulin degrading enzyme (IDE), a metalloendoprotease… CONTINUE READING

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