Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate

@article{deVoogt1987AndrogenAB,
  title={Androgen action blockade does not result in reduction in size but changes histology of the normal human prostate},
  author={Herman J. de Voogt and B. Ramanath Rao and Albert A. Geldof and L. J. G. Gooren and F. G. Bouman},
  journal={The Prostate},
  year={1987},
  volume={11}
}
The effect of androgen blockade on the normal human prostate was studied in 16 healthy volunteers opting for male‐to‐female gender reassignment. Their ages ranged from 19 to 27 years. After 8 weeks of treatment with Anandron, serum hormone levels indicated antiandrogenic action and physical signs of feminization appeared. Prostate volumes (measured by ultrasound) before and following Anandron treatment remained the same. After 18 months of treatment with cyproterone‐acetate and ethinyl… 

Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer

It is suggested that low doses of Anandron and estrogen can effectively be combined as a complete androgen counteracting therapy for hormone‐dependent prostatic carcinoma with minimal undesired side effects.

Androgen, estrogen, and progesterone receptors in normal and aging prostates

The chronological changes in the levels and distribution of steroid hormone receptors in normal prostatic tissue and the effect of such changes on the synthesis of growth factors, growth factor receptors, and oncogenes should be investigated.

HORMONAL REGULATION OF PROSTATE SPEClFlC ANTIGEN AND HUMAN GLANDULAR KALLlKRElN IN MALES AND FEMALES IN VIVO : EFFECTS OF ANDROGENS AND ANTIANDROGENS ON PLASMA AND URINARY PSA AND HK 2 LEVELS

The demonstrated in-vivo upreg ulation of PSA and hK2 by testosterone, and their in- vivo downregulation by CA may have clinical applications in hyperandrogenic females and prostate cancer patients.

Functional Morphology of Prostate Gland

These studies will advance the understanding of the mechanisms involved in the pathogenesis of prostate cancer and identify the biological mechanisms that hold the growing process under control.

Effects of combination endocrine treatment on normal prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma.

CET before radical prostatectomy causes regressive epithelial changes together with enhanced apoptosis and blocked mitotic activity and a differential effect on the non-neoplastic prostate was observed.

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